Professional and Linguistic Assessments Board (PLAB) Practice Exam

In the management of COPD, which combination is typically used after the initial SABA?

1. SABA + LABA

2. SABA + ICS

3. SABA + oral corticosteroids

4. SABA + LTRA

The correct answer is: SABA + ICS

The typical management of Chronic Obstructive Pulmonary Disease (COPD) emphasizes the use of bronchodilators to improve airflow and reduce symptoms. After the initial administration of a Short-Acting Beta-Agonist (SABA), the combination that is commonly employed is the SABA plus an Inhaled Corticosteroid (ICS). This combination is particularly effective because the SABA provides quick relief of acute symptoms by relaxing the muscles of the airways, while the ICS works to reduce inflammation within the airways, which is a significant underlying issue in COPD. The use of an ICS can help to decrease the frequency of exacerbations and improve overall lung function. The other options, while they include valid medications for various respiratory conditions, do not align with the standard progression of treatment for COPD after the use of a SABA in this specific context. For instance, while a Long-Acting Beta-Agonist (LABA) can also be used in combination therapy, it does not usually follow an acute SABA intervention in the initial management strategy. Oral corticosteroids are reserved for exacerbations rather than routine maintenance in stable COPD. Lastly, Leukotriene Receptor Antagonists (LTRA) are not a standard