Professional and Linguistic Assessments Board (PLAB) Practice Exam

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What is the primary treatment for MgSO4 toxicity?

  1. Stop magnesium administration

  2. Administer oxygen therapy

  3. Increase fluid intake

  4. Provide intravenous antibiotics

The correct answer is: Stop magnesium administration

The primary treatment for magnesium sulfate (MgSO4) toxicity is to cease its administration. Magnesium sulfate is commonly used in various therapeutic contexts, including managing seizures in eclampsia and for tocolysis in preterm labor. However, excessive levels of magnesium can lead to serious side effects, including respiratory depression, hypotension, and cardiac arrest. When magnesium toxicity manifests, the immediate and effective action is to stop any further magnesium infusion or administration. This helps to prevent additional magnesium from contributing to these adverse effects. Other interventions may be necessary based on the severity of the toxicity, such as administering intravenous calcium to counteract the effects of magnesium on the heart, but the first step in management is to halt magnesium administration to allow the body's metabolism and excretion processes to restore normal magnesium levels.